Hilliman, who rushed for a season-high 119 yards and a touchdown in Saturday’s win over Northern Illinois, was injured late in the game.
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He rushed for 860 yards and a team-high 13 touchdowns in 2014 but had been off to a slow start until Saturday.
BC (3-1) had no timetable for his potential return, leaving junior Tyler Rouse (28 carries, 161 yards and five TDs) to shoulder the bulk of the team’s running game.
Hilliman’s injury comes a week after BC lost starting quarterback Darius Wade (broken ankle) for the season.
The Eagles, 0-1 in the ACC, play at Duke (3-1, 1-0) Saturday.
